@Ravi Kiran - Please see https://drive.google.com/open?id=1dzrDQx--5cJpN8bASs_lANesqQzmbQNT
for my current folders with: Resources, Plug-Ins, Scripts, Configuration and Presets

Again see https://drive.google.com/file/d/1Vc-i-epxilfFeHBV5C9CUEqSoQSvACq9/view for a video capture of the issue as it presents itself in the PDF export dialogues.

The drop down menu doesn't allow you to change between cmyk and rgb when exporting a jpeg file, sometimes the program get back to work after restarting, sometimes not.

iMac (Retina 5K, 27-inch, Late 2015)
Indesign current version

@Ravi Kiran - Please see https://drive.google.com/file/d/1Vc-i-epxilfFeHBV5C9CUEqSoQSvACq9/view for a video capture of the issue as it presents itself in the PDF export dialogues. Will copy Preferences and Cache next...

Hi,

Any news on this?
I also have the same problem. All mouse-click menus are disabled. It seems that the 1st time you select a menu option it works but then it stops working all together. First ones to become disabled were find/change options, now I can´t even select a font. Nothing is working. I re-installed indesign but it stays the same. I working with Indesign cc 2018 and Os High Sierra 10.13.3. and I never had this issue with any previous versions of Indesign. Please help!

This issue seems to affect ALL drop down menus within the PDF export dialogue. It also affects drop downs when exporting as an eps file, not just PDF.

I am unable to toggle between options in the PDF Presets, Standard and Compatibility dropdowns in InDesign. This issue cropped up suddenly and recently, after updating the application via Creative Cloud. I have seen this issue before during a previous update. See video for demonstration of the bug:
https://drive.google.com/file/d/1Vc-i-epxilfFeHBV5C9CUEqSoQSvACq9/view

I also experience this issue, which cropped up after an update installed in February 2018. I am unable to switch between presets in the PDF export dialogue. Also unable to make similar toggles even when exporting as an eps file.

Any help on this issue?

Same here! Vertical alignment, table styles, you name it.

I have this happen about 4-5 times a week. It seems to me that something triggers it because it isn't always a problem when first starting InDesign. To perhaps reiterate what has been said in previous comments; this exists in CC2015, CC2017 and CC2018 in Sierra and High Sierra. (Haven't tested versions older than that.) It also exists in InCopy.

Same issue for me but thanks BRIDGET for the tip about using keystrokes!
Will use this for now

Same issue for me - ever since updating to High Sierra (10.13.3). Using the latest Creative Cloud - InDesign.

Only works when I use the arrow keys/enter within the Preset dropdown menu. Mouse clicks don't register the selection.

Have no ability to edit the bullets and numbering elements of a document.
Updated to CC yesterday and have a deadline today!

CC 2018
I can't choose a different PDF Preset. It just stays on the one i used last. To change the preset I have to quit indesign a few times until i can change it.

Same issue - needs to be fixed so that I can make artwork for print
Sierra 10.12.6
I can't believe this problem is festering with no help from Adobe...

Same issue. High Sierra 10.13.3

It is now Feb. 12 2018

Same issue. Moving the mouse down from File causes a different drop down menu to appear. At least yesterday that was the case. Interestingly yesterday it was only File, Edit and Layout that caused the Window or Help to drop. Now File works fine and all the other menu items drop the a menu to the left. Deleting the preference file on opening had no effect. I've been unable to locate the pref and cache files in file manager.
Windows 10
13.0.1 x 64

When I click in a dialog box, like to change a font, edit a paragraph style, etc, it does not work. It only works when I use my keyboard to scroll and hit enter.

This just started happening 2 days ago. I have not changed my OS or CC version. Currently using Indesign CC 13.0.1.

This is a SERIOUS issue! How can it have gone on this long and not been addressed? CC2018 export was working fine and now I am experiencing this too. I am also unable to select a printer. They show - but I can't change from Post Script option.

I have OS X EL Capitan 10.11.6 and have the same issue. Sometimes I can select print presets and other times I have to use the arrow keys. All of them show up white, as to select them but, will not unless using the arrow keys majority of the time. With technology, there is NO EXCUSE for such poor programming. Instead of Adobe Indd, our company is going toward - Scribus. The industry needs something that actually works.