This is happened three times now. The guides appear on the screen is white even though there specified color in preferences still the default. The white areas on the screen such as the page and pasteboard color is light yellow.

The first time resetting the preferences fixed it. The second time it did not but re-profiling the monitor did. The third time neither fixed it and after rebooting InDesign gave me the "configuration error", "error 16".

I followed the instructions for this error that I found here:
https://helpx.adobe.com/creative-cloud/kb/configuration-error.html#mac_os

Since this happened InDesign seems to be less stable and before and has crashed on me several times when I was quitting the program.

The next time the error occurs I will attempt to get a screenshot.

Mac Pro, OSX 10.11.6, InDesign 12.0.0.81 (And no I will not update InDesign to see if this fixes the issue)