Since updating to 21.1 (2026), I have to repair the Visual C++ Redistributables, restart, and then reset preferences with Shift+Ctrl+Alt just to get InDesign to open. Error OXC0000142. I have done this numerous times, and each week, I have to do it again.

It also has crashed my (and others on our team) computers which makes them boot into the BIOS to a Support Repair screen.

21.1 is near unusable at this point.