I would love to be able to control optical margin alignment on a per character basis. This is possible in, for example, Affinity Publisher. There, the user can choose No alignment, default optical alignment (as embedded in the font), or manual (allowing the user to make adjustments if needed). See image. I'm genuinely surprised that InDesign's optical alignment feature is so limited, primitive even.

But please modify this comment so that it applies to "non word-forming characters" i.e., not just punctuation.
u02C6 is a word-forming character, but optical margin alignment treats it as punctuation. It should be treated as a letter.

This suggestion of a individual kerning editor leads to similar possibilities:
https://indesign.uservoice.com/forums/601021-adobe-indesign-feature-requests/suggestions/31111675-kerning-editor-with-individual-margin-alignment-o

It would also be great to have it apply to only some punctuation marks—quotation marks, for instance, hang much farther into the gutter than other punctuation.

Amen

I would love this feature.

I work for a large company and our brand uses fully justified text on all of our artwork. I can't bring myself to turn Optical Margin Alignment on because alphabetical characters become too ragged on the left hand side of the column. So we put up with punctuation looking bad on the right hand side of the column. Changing the point size in the Story palette doesn't seem to help. It's impossible to get a nice looking paragraph of fully justified text if a full stop or comma happens to fall at the end of a line.