InDesign 2025 & 2026 (v21.0 & v20.5.1)
PC running Windows 11 Pro
CPU: AMD Ryzen 9 9950X3D 16-Core Processor
GPU: NVIDIA GeForce RTX 5070 Ti
Display: ASUS ProArt PA279CRV @3840x2160
RAM: 64GB DDR5 @6000 MT/s
Storage: Samsung SSD 9100 PRO 2TB

There are mainly 3 issues, that have not improved with the new version:

1. Animated zoom is broken; it's laggy, and does not zoom in on the actual point of focus where you click with your cursor, making it worse and slower to use than CPU Preview's regular zoom, and in many cases it literally zooms you in on a point outside the artboard and out of your page. The same issue was described in an older bug and was marked as "fixed" when in fact it wasn't. (https://indesign.uservoice.com/forums/601180-adobe-indesign-bugs/suggestions/50037261--id-4264855-issue-with-animated-zoom-in-gpu )

2. Panning/using the hand tool while zoomed in on a page containing pictures, with "Display Performance" set to "High Quality Display", with GPU Accelerated Preview is slow and causes massive stutters compared to CPU Preview, its stuttering is very irregular it ends up causing eye strain and headaches after long use. The issue is not present with "Typical Display", but at that stage the performance is the same as CPU Preview so makes you wonder what's the point.

3. When working on a text layout and adjusting the flow of the text, when the end of the text moves from the last page to the page before, GPU Preview sometimes keeps a ghost of the last page containing text, even though the page before is now showing the updated content. CPU Preview shows it correctly. It can only be fixed by entering some new text into the original "last" page forcing it to refresh the preview.

The first two issues are constant and are the most critical, as they make InDesign quite frustrating to use, and make GPU acceleration completely useless.

I couldn't add a video of #3 as the content of the pages was confidential, but will try to take a video when it happens again on a different document.