This seems to happen randomly, but while working on an InDesign doc these keys will stop working and the only fix is to restart my entire laptop. This doesn't really fix anything though because the issue can happen again within minutes of starting back up.

I use shift and alt a lot to align assets on my pages as well as duplicate certain assets. Among a bunch of other things.

This happens across all version I use (2019, 2020 and 2021)