'Apply italic' Shortcut Issue
Prior to v16, Shift-Command-I applied the active font's italic to selected text. But in v16, it is applying the font's bold italic.
I see no way to affect this in the Keyboard shortcuts panel. It simply lists "Apply italic" with the correct shortcut.

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Henrique Beier commented
I am facing this issue as well.
From what I could gather, this bug happens only with TTF fonts of large families (more styles than the default 4: Regular, Italic, Bold and Bold Italic). When applying italics via shortcut, InDesign applies the Italic of a different weight, not necessarily the Bold Italic. I have seen Medium Italic, Light Italic and SemiBold Italic.
You can test it with Avenir Next Condensed on a Mac. See the attached image.
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manisha thapliyal commented
I am facing the same issue. Kindly resolve this as soon as possible. It is affecting my day to day work