I have saved pdf profiles that arbitrarily change some of their settings without warning. Specifically, the profile inclusion policy changes from "include all RGB and tagged source profiles" to "include all profiles", and marks change from only crops and bleeds being checked, to also include page information. I go back and edit the profile to fix them back the way I need them, then some time down the road they change again. This happens on all of our workstations, and has been happening for years. If we don't catch it when these arbitrarily change, it can cause major color and imposition issues.

Indesign 14.01 and all earlier versions
Need to export files of various color makeups, profiles, etc. to eventually get it to happen. It may happen several times in one day, or not for weeks. VERY arbitrary.