When working in a document whose intent is Web or Mobile it would be great if InDesign had an option to force users to work in whole pixels.

Not to be confused with InDesign's "Snap to Document Grid", what I am thinking is something more like Photoshop's behaviour when your Preferences -> Tools has "Snap Vector Tools and Transforms to Pixel Grid" selected.

The outcome would be that you could never have a page item with floating point values.