It's a very logn known issue in InDesign: Different font sizes have different spacings to left or right edge of the frame. The more the font size grows, the more the space to left or right edge of the text frame grows.
From time to time in the past years my clients have noticed that in drafts for correction. This means a lot of additional manual work for large projects in order to align the font correctly.
It would be great and an enormous relief if in one of the next versions the text frames are either already correctly preset, or if there would be the possibility in the style sheets to set the left or right alignment accordingly.