For some users, straight quotes and apostrophes are the bane of our existence. The Use Typographer's Quotes checkbox is in Preferences>Type is (strangely) document-dependent and may switch off if you have a document open that originated on another machine.
It's rather annoying to have to keep popping back into Preferences. Is there a possibility we could have an option to have it ALWAYS enabled, so that it overrides individual document settings?