Fix for this issue is now available in the latest update of InDesign 2021 – that is, InDesign 16.2.1
In the Creative Cloud Desktop application, click on the Updates section on the left. You should be able to see the Update available for InDesign. Please update your InDesign application to this version to try out the fix.
Let us know in the comments section if you still face this problem.
Adobe InDesign Team
An error occurred while saving the commentCooper commented
I had the same issue, only work around I found was to use web ready versions of the images instead of the high res versions. No good for print but for web you can get away with it.